Chronic graft-versus-host disease: clinical manifestation and therapy
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چکیده
منابع مشابه
Chronic graft-versus-host disease.
Mr. F is a 62-year-old Caucasian man who was diagnosed with acute myelogenous leukemia (AML) 15 months prior. Following two cycles of induction chemotherapy, his AML was in remission. Four months ago, after a reduced-intensity conditioning regimen, Mr. F received an allogeneic peripheral blood stem cell transplant from his human leukocyte antigen–identical 56year-old sister. Mr. F received a re...
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Chronic graft-versus-host disease (GVHD) is the most common late complication of allogeneic bone marrow transplantation (BMT). The sclerodermatous form of the disease is often refractory to standard treatment modalities. Based on reports of response to etretinate, a synthetic retinoid, among patients with scleroderma, we have added etretinate to the treatment regimen of 32 patients with refract...
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Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixteen patients (20%) had a sustained response, 9 with a complete remission and 7...
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متن کاملChronic polyarthritis and graft-versus-host disease.
SIR—In previous studies, the presence of arthralgias and transitory arthritis in graft-versus-host disease (GVHD) has been reported, but not chronic arthritis. We will consider a case of non-erosive polyarthritis after a bone marrow transplantation in the context of chronic GVHD. A 32-yr-old male was diagnosed at the age of 27 as having acute myeloblastic leukosis. One year after the diagnosis,...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2001
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1703111